Our first meeting was a success!
1) List 4 types of vaccines:
-live attenuated (pathogen is alive, but weakened)
-inactivated (pathogen is dead)
-subunit (just a piece of the pathogen + an 'adjuvant' like alum)
-toxoid (the toxin produced by the pathogen, chemically inactivated)
2) Model them with donuts:
-scraped off the frosting (measles, mumps, chickenpox)
-smashed (polio, Hep A, rabies)
-sprinkles only + alum adjuvant (Hep B, pertussis, HPV)
-cream filling 'toxin' (diphtheria, tetanus)
3) We examined the kitchen-shelf version of alum (used for canning vegetables) and went over how it stimulates the immune system and is used in subunit vaccines.
4) Wet lab: Alexi made her very own REAL vaccine!
-protein from the inside of the flu virus + alum + saline
5) Centrifuge vaccines to demonstrate that protein is fully adsorbed (stuck to) to alum
6) Inject real research subjects: nine 'black 6' mice
-injected intramuscularly, just like how most vaccines are given to humans
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